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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-4-6
|
| pubmed:abstractText |
A series of 17 beta-carbamoyl-1,3,5(10)-estratriene-3-carboxylic acids has been prepared and evaluated in vitro as inhibitors of human and rat prostatic steroid 5 alpha-reductase (EC 1.3.1.30). Potent inhibition of the human enzyme, in particular, was observed and preliminary studies using rat enzyme suggest that the inhibition results from the formation of an enzyme-NADP(+)-inhibitor complex. The compounds were synthesized from estrone, generally employing a differentiated bis-triflate carbonylation strategy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
937-42
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2308144-5-alpha Reductase Inhibitors,
pubmed-meshheading:2308144-Animals,
pubmed-meshheading:2308144-Carboxylic Acids,
pubmed-meshheading:2308144-Humans,
pubmed-meshheading:2308144-Male,
pubmed-meshheading:2308144-Prostate,
pubmed-meshheading:2308144-Rats,
pubmed-meshheading:2308144-Structure-Activity Relationship
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Steroidal A ring aryl carboxylic acids: a new class of steroid 5 alpha-reductase inhibitors.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, Smith Kline & French Laboratories, King of Prussia, Pennsylvania 19406.
|
| pubmed:publicationType |
Journal Article
|