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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-4-3
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pubmed:abstractText |
2-Deoxy-D-glucose (2-DOG) uptake was tested in human fibroblast cultures in the presence and absence of vitamin E. Addition of 10 micrograms/ml vitamin E to the culture medium significantly reduced this uptake for 2-DOG concentrations of 0.005 to 10 mmol/liter (P less than or equal to 0.01). The decrease of 2-DOG uptake was inversely proportional to the rise in 2-DOG concentration (P less than or equal to 0.01). The presence of vitamin E reduced by 71% the average cellular level of lipid peroxides (expressed as thiobarbituric acid reactive substances) and caused a small but significant decrease in the cholesterol concentration (P less than or equal to 0.01). These last results might explain the decrease in 2-DOG uptake observed in the presence of vitamin E.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxy Sugars,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0883-8364
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
29-32
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2307637-Biological Transport,
pubmed-meshheading:2307637-Cell Division,
pubmed-meshheading:2307637-Cells, Cultured,
pubmed-meshheading:2307637-Cholesterol,
pubmed-meshheading:2307637-Deoxy Sugars,
pubmed-meshheading:2307637-Deoxyglucose,
pubmed-meshheading:2307637-Fibroblasts,
pubmed-meshheading:2307637-Humans,
pubmed-meshheading:2307637-Kinetics,
pubmed-meshheading:2307637-Lipid Peroxides,
pubmed-meshheading:2307637-Skin,
pubmed-meshheading:2307637-Vitamin E
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pubmed:year |
1990
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pubmed:articleTitle |
Effect of vitamin E on 2-deoxy-D-glucose uptake in human fibroblast cultures.
|
pubmed:affiliation |
Unité de Recherche d'Hépatologie Pédiatrique INSERM U 56 et Laboratoire Central de Biochimie, Hôpital de Bicêtre, France.
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pubmed:publicationType |
Journal Article,
In Vitro
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