Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1990-3-19
|
| pubmed:abstractText |
We examined the expression of alpha-calcitonin gene-related peptide (alpha-CGRP) and beta-CGRP mRNAs in the rat dorsal root ganglion (DRG) using in situ hybridization histochemistry with oligonucleotide probes. Analysis of autoradiograms showed that alpha-CGRP mRNA labeled 36.4% of all DRG neurons and beta-CGRP mRNA labeled 30.8%. Small and medium-sized neurons expressed both types of mRNA, but large neurons showed a predominance of alpha-CGRP mRNA expression. The colocalization of alpha-CGRP and beta-CGRP mRNAs was shown at a cellular level in consecutive DRG sections. Thus, we demonstrated that alpha-CGRP and beta-CGRP were distributed differently in the DRG neurons, although genes coding for these neuropeptides coexist in the small or medium-sized neurons.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
108
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-5
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2304619-Animals,
pubmed-meshheading:2304619-Calcitonin Gene-Related Peptide,
pubmed-meshheading:2304619-Ganglia, Spinal,
pubmed-meshheading:2304619-Gene Expression Regulation,
pubmed-meshheading:2304619-Male,
pubmed-meshheading:2304619-Nucleic Acid Hybridization,
pubmed-meshheading:2304619-RNA, Messenger,
pubmed-meshheading:2304619-Rats,
pubmed-meshheading:2304619-Rats, Inbred Strains
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Co-expression of alpha-CGRP and beta-CGRP mRNAs in the rat dorsal root ganglion cells.
|
| pubmed:affiliation |
Department of Anatomy II, Osaka University Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|