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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1990-3-26
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pubmed:abstractText |
A single intraperitoneal injection of pregnant mice with a monovalent Formalin-inactivated influenza A virus vaccine protected their offspring against a lethal challenge dose of the same influenza A virus H3N2, H2N2, and H1N1 subtypes, as well as against challenge with the other two subtypes. Degree of protection was vaccine dose related. Cross-fostering of neonates indicated that protection was conferred by breast milk antibodies. Serum virus-specific neutralizing antibodies in the mothers and neonates correlated with resistance to vaccine virus, but were detected against other subtypes only in a complement enhancement test or when high doses of vaccine were given.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-227920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-2732721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-2846987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-303568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-306410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3114381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3668509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3773053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3817868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3839001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-3945639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-47313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-479636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-583151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-606792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-621378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6224092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6257108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6260835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6273293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6295944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6584913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6606679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6745992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6848601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6970126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6972261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-6997968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-7091222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-7191866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-7396454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-7462695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2304146-7466327
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1370-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2304146-Animals,
pubmed-meshheading:2304146-Animals, Newborn,
pubmed-meshheading:2304146-Antibodies, Viral,
pubmed-meshheading:2304146-Cross Reactions,
pubmed-meshheading:2304146-Female,
pubmed-meshheading:2304146-Immunity, Maternally-Acquired,
pubmed-meshheading:2304146-Influenza A virus,
pubmed-meshheading:2304146-Mice,
pubmed-meshheading:2304146-Mice, Inbred Strains,
pubmed-meshheading:2304146-Neutralization Tests,
pubmed-meshheading:2304146-Orthomyxoviridae Infections,
pubmed-meshheading:2304146-Pregnancy,
pubmed-meshheading:2304146-Pregnancy, Animal,
pubmed-meshheading:2304146-Species Specificity,
pubmed-meshheading:2304146-Vaccination,
pubmed-meshheading:2304146-Vaccines, Attenuated
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pubmed:year |
1990
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pubmed:articleTitle |
Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes.
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pubmed:affiliation |
Influenza Research Center, Baylor College of Medicine, Houston, Texas 77030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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