Linked Life Data

2303161

Source:http://linkedlifedata.com/resource/pubmed/id/2303161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-3-27
pubmed:abstractText
A number of mRNAs present in kidney are selectively induced by the administration of androgen to mice. Using a pulse-labelling method to measure in vivo rates of mRNA synthesis, seven androgen-responsive mRNAs were tested. The time courses of induction following testosterone treatment indicated that androgen-responsive mRNA synthesis increases progressively. Depending on the mRNA examined, it took 2-10 days after the start of hormone administration for synthesis rates to reach a maximum. Even the fastest of these inductions is slow compared to response times in other steroid-responsive systems, and is very slow compared to the time required for androgen-receptor complex to accumulate in the nucleus. We conclude that gene activation in response to androgen is a prolonged and incremental process rather than a single event. Two alternative models are proposed: (1) these genes are actually responding to intermediate transcription factors that accumulate progressively in response to androgen; (2) the androgen-responsive genes contain multiple binding sites that have a cumulative effect on transcription as the number of receptor complexes bound increases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-74
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Progressive induction of mRNA synthesis for androgen-responsive genes in mouse kidney.
pubmed:affiliation
Department of Genetics, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.