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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1990-3-15
|
| pubmed:abstractText |
Cardiovascular disease risk factors were measured 10-15 years (mean, 11.9 years) prior to the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus in Rancho Bernardo, California. There were 1,847 men and women aged 40-79 years who had no known diabetes or fasting hyperglycemia at baseline (1972-1974). At the follow-up examination (1984-1987), 1,115 men and women (60.4%) had normal glucose tolerance, 513 (27.8%) had impaired glucose tolerance, and 219 (11.9%) had non-insulin-dependent diabetes mellitus as defined by World Health Organization criteria. Rates of impaired glucose tolerance and non-insulin-dependent diabetes mellitus increased with age, and impaired glucose tolerance was approximately twice as common as non-insulin-dependent diabetes mellitus. Those with non-insulin-dependent diabetes mellitus were older and more overweight and had higher levels of blood pressure, fasting plasma glucose, and triglyceride at baseline than those whose glucose tolerance remained normal; those with impaired glucose tolerance generally had intermediate levels of the same risk factors. When it was examined in a prospective fashion, in general, the age-adjusted risk of non-insulin-dependent diabetes mellitus increased with increasing quartile of each risk factor, and the risk of non-insulin-dependent diabetes mellitus in a given quartile was greater than that for impaired glucose tolerance. Logistic regression analyses showed these factors to be positively associated with a subsequent diagnosis of impaired glucose tolerance as well as non-insulin-dependent diabetes mellitus in women, and to a lesser degree in men, independent of baseline age and body mass index (weight (kg)/height (m)2). These data illustrate that a less favorable cardiovascular risk factor profile precedes the diagnosis of both non-insulin-dependent diabetes mellitus and impaired glucose tolerance.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0002-9262
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
443-53
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2301354-Adult,
pubmed-meshheading:2301354-Aged,
pubmed-meshheading:2301354-Aging,
pubmed-meshheading:2301354-Blood Glucose,
pubmed-meshheading:2301354-Blood Pressure,
pubmed-meshheading:2301354-Body Mass Index,
pubmed-meshheading:2301354-California,
pubmed-meshheading:2301354-Cardiovascular Diseases,
pubmed-meshheading:2301354-Cholesterol,
pubmed-meshheading:2301354-Cohort Studies,
pubmed-meshheading:2301354-Diabetes Mellitus, Type 2,
pubmed-meshheading:2301354-Female,
pubmed-meshheading:2301354-Glucose Tolerance Test,
pubmed-meshheading:2301354-Humans,
pubmed-meshheading:2301354-Male,
pubmed-meshheading:2301354-Middle Aged,
pubmed-meshheading:2301354-Risk Factors,
pubmed-meshheading:2301354-Sex Factors,
pubmed-meshheading:2301354-Smoking,
pubmed-meshheading:2301354-Triglycerides
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Cardiovascular disease risk factors prior to the diagnosis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus in a community of older adults.
|
| pubmed:affiliation |
Department of Community and Family Medicine, School of Medicine, University of California, San Diego, La Jolla 92093.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|