Linked Life Data

230053

Source:http://linkedlifedata.com/resource/pubmed/id/230053

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-3-24
pubmed:abstractText
Relative dendritic atrophy has been reported in hippocampal granule cells of senescent (25 month) as compared to young (3 month) rats. An electrophysiological study of synaptic response waveform was un;ertaken to determine whether these anatomical changes have physiological correlates of functional significance to the integrative capacity of the granule cells. The variable of interest was the rist time of the extracellularly recorded population synaptic response because this parameter (under appropriate conditions) has been shown to reflect relative electrotonic distance of active synapses from the spike generating zone located near the cell body. By selectively stimulating small subsets of perforant path fibers along its medio-lateral axis, synapses at increasing distances from the soma may be activated and the response waveform recorded. Systematic observations were made on both hemispheres of 3 adolescent (2 months), three middle-aged (12 months), and 3 senescent (28 months) rats. There were no significant differences in the mean, variance, or range of the frequency distributions of synaptic response rise times. However, the medians of the distributions revealed a small shift towards lower values with advanced age. Although the latter finding is consistent with the anatomical changes, the magnitude of the differences were so small as to make their functional significance dubious.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0361-073X
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-206
pubmed:dateRevised
2008-2-25
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Neurophysiological comparison of dendritic cable properties in adolescent, middle-aged, and senescent rats.
pubmed:publicationType
Journal Article