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| pubmed-article:2299665 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2299665 | pubmed:dateCreated | 1990-3-13 | lld:pubmed |
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| pubmed-article:2299665 | pubmed:abstractText | A novel human brain complementary DNA sequence encodes n-chimaerin, a 34,000 Mr protein. A single cysteine-rich sequence CX2CX13CX2CX7CX7C in the N-terminal half of n-chimaerin shares almost 50% identity with corresponding sequences in the C1 regulatory domain of protein kinase C. The C-terminal half of n-chimaerin has 42% identity with the C-terminal region (amino acid residues 1050 to 1225) of BCR, the product of the breakpoint cluster region gene involved in Philadelphia (Ph') chromosome translocation. n-Chimaerin mRNA (2.2 x 10(3) base-pairs) is specifically expressed in the brain, with the highest amounts being in the hippocampus and cerebral cortex. The mRNA has a neuronal distribution and is expressed in neuroblastoma cells, but not in C6 glioma or primary astrocyte cultures. The similarity of two separate regions of n-chimaerin to domains of protein kinase C and BCR has intriguing implications with respect to its evolutionary origins, its function in the brain and potential phorbol-ester-binding properties. | lld:pubmed |
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| pubmed-article:2299665 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2299665 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2299665 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2299665 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2299665 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:SmithPP | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:FIXR CRC | lld:pubmed |
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| pubmed-article:2299665 | pubmed:author | pubmed-author:AhmedSS | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:LeungTT | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:HaleHH | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:KozmaRR | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:MonfriesCC | lld:pubmed |
| pubmed-article:2299665 | pubmed:author | pubmed-author:Vanniasingham... | lld:pubmed |
| pubmed-article:2299665 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2299665 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2299665 | pubmed:volume | 211 | lld:pubmed |
| pubmed-article:2299665 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2299665 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2299665 | pubmed:pagination | 11-6 | lld:pubmed |
| pubmed-article:2299665 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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| pubmed-article:2299665 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2299665 | pubmed:articleTitle | Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene. | lld:pubmed |
| pubmed-article:2299665 | pubmed:affiliation | Department of Neurochemistry, Institute of Neurology, London, U.K. | lld:pubmed |
| pubmed-article:2299665 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2299665 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2299665 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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