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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0006556,
umls-concept:C0033634,
umls-concept:C0033684,
umls-concept:C0067895,
umls-concept:C0086418,
umls-concept:C0205314,
umls-concept:C0220905,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0679058,
umls-concept:C0679622,
umls-concept:C0812385,
umls-concept:C1514468,
umls-concept:C1514562,
umls-concept:C1547699,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2700640
|
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-3-13
|
| pubmed:databankReference | |
| pubmed:abstractText |
A novel human brain complementary DNA sequence encodes n-chimaerin, a 34,000 Mr protein. A single cysteine-rich sequence CX2CX13CX2CX7CX7C in the N-terminal half of n-chimaerin shares almost 50% identity with corresponding sequences in the C1 regulatory domain of protein kinase C. The C-terminal half of n-chimaerin has 42% identity with the C-terminal region (amino acid residues 1050 to 1225) of BCR, the product of the breakpoint cluster region gene involved in Philadelphia (Ph') chromosome translocation. n-Chimaerin mRNA (2.2 x 10(3) base-pairs) is specifically expressed in the brain, with the highest amounts being in the hippocampus and cerebral cortex. The mRNA has a neuronal distribution and is expressed in neuroblastoma cells, but not in C6 glioma or primary astrocyte cultures. The similarity of two separate regions of n-chimaerin to domains of protein kinase C and BCR has intriguing implications with respect to its evolutionary origins, its function in the brain and potential phorbol-ester-binding properties.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-2836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
|
| pubmed:volume |
211
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-6
|
| pubmed:dateRevised |
2009-9-29
|
| pubmed:meshHeading |
pubmed-meshheading:2299665-Amino Acid Sequence,
pubmed-meshheading:2299665-Base Sequence,
pubmed-meshheading:2299665-Brain,
pubmed-meshheading:2299665-Chimerin 1,
pubmed-meshheading:2299665-DNA,
pubmed-meshheading:2299665-Gene Expression,
pubmed-meshheading:2299665-Genes,
pubmed-meshheading:2299665-Humans,
pubmed-meshheading:2299665-Molecular Sequence Data,
pubmed-meshheading:2299665-Molecular Weight,
pubmed-meshheading:2299665-Multigene Family,
pubmed-meshheading:2299665-Nerve Tissue Proteins,
pubmed-meshheading:2299665-Philadelphia Chromosome,
pubmed-meshheading:2299665-Protein Kinase C,
pubmed-meshheading:2299665-RNA, Messenger,
pubmed-meshheading:2299665-Restriction Mapping,
pubmed-meshheading:2299665-Sequence Homology, Nucleic Acid
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.
|
| pubmed:affiliation |
Department of Neurochemistry, Institute of Neurology, London, U.K.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|