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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1990-3-9
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pubmed:abstractText |
A novel series of 14 alpha-methyl-15-aza-D-homosterols 3-7 has been synthesized. These compounds display significant antimycotic activity in vitro (MIC = 0.8-3.1 micrograms/mL) that compares quite favorably to the activity observed for fluconazole (MIC = 0.8 micrograms/mL). Azasterols 3 and 4 were active in vivo as reflected in the increased survival time of Candida albicans infected mice. The antimycotic activity of 3-7 is hypothesized to be a consequence of the inhibition of fungal 14,15-sterol reductase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-2623
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
877-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2299651-Animals,
pubmed-meshheading:2299651-Antifungal Agents,
pubmed-meshheading:2299651-Candidiasis,
pubmed-meshheading:2299651-Chemistry, Physical,
pubmed-meshheading:2299651-Drug Design,
pubmed-meshheading:2299651-Mice,
pubmed-meshheading:2299651-NADH, NADPH Oxidoreductases,
pubmed-meshheading:2299651-Oxidoreductases,
pubmed-meshheading:2299651-Physicochemical Phenomena,
pubmed-meshheading:2299651-Sterols
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Design and synthesis of 14 alpha-methyl-15-aza-D-homosterols as novel antimycotics.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, Smith Kline & French Research Limited, Welwyn, Hertfordshire, U.K.
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pubmed:publicationType |
Journal Article
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