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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-3-15
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pubmed:abstractText |
1. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM). 3. From these experiments it is concluded that nimodipine and nitrendipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the guinea-pig ileum. 4. Nisoldipine resulted to be the most active agent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0306-3623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2298388-Acetylcholine,
pubmed-meshheading:2298388-Animals,
pubmed-meshheading:2298388-Calcium,
pubmed-meshheading:2298388-Dihydropyridines,
pubmed-meshheading:2298388-Electric Stimulation,
pubmed-meshheading:2298388-Guinea Pigs,
pubmed-meshheading:2298388-Ileum,
pubmed-meshheading:2298388-Male,
pubmed-meshheading:2298388-Muscle, Smooth,
pubmed-meshheading:2298388-Muscle Contraction,
pubmed-meshheading:2298388-Myenteric Plexus,
pubmed-meshheading:2298388-Potassium Chloride
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pubmed:year |
1990
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pubmed:articleTitle |
Dihydropyridines on guinea-pig ileum.
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pubmed:affiliation |
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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