Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-3-8
|
| pubmed:abstractText |
Ferrokinetics and erythropoiesis were examined in mice exposed for 6 or 7 weeks to an airborne concentration of 300 ppm of benzene, for 6 h per day, and 5 days per week. Ferrokinetic indicators showed only a slightly enhanced production of haeme and erythrocytes in the spleen (133% +/- 18% and 122% +/- 17%, respectively). Production did not change in the femoral marrow; a decline of CFU-C, BFU-E and especially CFU-E (34% +/- 8%) took place there and a shift of cellularity into less mature developmental classes in the erythroblast compartment, without this compartment as a whole being damaged. The erythrocytes produced have an enhanced MCV (109% +/- 0%) and MCH (109% +/- 1%) with an unchanged MCHC; their concentration in blood sank to 87% +/- 1%. The absolute reticulocyte count rose to 160% +/- 16%. 59Fe incorporation into the liver declined far below the level attributable to decreased accessibility of the tracer (84% +/- 4%). A shortening of the life span of late erythroblasts and circulating erythrocytes was deduced from these findings and methodological problems related to some of the seemingly controversial findings are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-5242
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
41-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2297584-Administration, Inhalation,
pubmed-meshheading:2297584-Animals,
pubmed-meshheading:2297584-Benzene,
pubmed-meshheading:2297584-Bone Marrow,
pubmed-meshheading:2297584-Colony-Forming Units Assay,
pubmed-meshheading:2297584-Erythroblasts,
pubmed-meshheading:2297584-Erythrocyte Aging,
pubmed-meshheading:2297584-Erythrocyte Count,
pubmed-meshheading:2297584-Erythrocytes,
pubmed-meshheading:2297584-Erythropoiesis,
pubmed-meshheading:2297584-Female,
pubmed-meshheading:2297584-Iron,
pubmed-meshheading:2297584-Iron Radioisotopes,
pubmed-meshheading:2297584-Kinetics,
pubmed-meshheading:2297584-Mice,
pubmed-meshheading:2297584-Mice, Inbred C57BL,
pubmed-meshheading:2297584-Mice, Inbred DBA,
pubmed-meshheading:2297584-Spleen
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Ferrokinetics and erythropoiesis in mice after long-term inhalation of benzene.
|
| pubmed:affiliation |
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
|
| pubmed:publicationType |
Journal Article
|