| pubmed-article:2297560 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2297560 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:2297560 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:2297560 | lifeskim:mentions | umls-concept:C0007066 | lld:lifeskim |
| pubmed-article:2297560 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2297560 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:2297560 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2297560 | pubmed:dateCreated | 1990-3-5 | lld:pubmed |
| pubmed-article:2297560 | pubmed:abstractText | Aromatic monocarboxylic acids are known to significantly potentiate the mechanical response of skeletal muscle fibers. In this study we investigated the effects of enantiomers of 2-(4-chlorophenoxy)propionic acid, chemically one of the simplest aromatic monocarboxylic acids with chiral properties, on mechanical threshold and charge movement in frog skeletal muscle. The R(+), but not the S(-), enantiomer lowered rheobase mechanical threshold and shifted charge movement to more negative potentials. The R(+) enantiomer also significantly slowed charge movement kinetics, with pronounced delays of the OFF charge transitions. These effects required high temperature for their production. The stereospecific actions of the R(+) enantiomer are interpreted in terms of a specific interaction of this compound at an anion-sensitive site involved in excitation-contraction coupling, most likely on the dihydropryidine-sensitive voltage sensor in the T-system. | lld:pubmed |
| pubmed-article:2297560 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2297560 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2297560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2297560 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2297560 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2297560 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:2297560 | pubmed:author | pubmed-author:BryantS HSH | lld:pubmed |
| pubmed-article:2297560 | pubmed:author | pubmed-author:Conte-Camerin... | lld:pubmed |
| pubmed-article:2297560 | pubmed:author | pubmed-author:TortorellaVV | lld:pubmed |
| pubmed-article:2297560 | pubmed:author | pubmed-author:HeinyJ AJA | lld:pubmed |
| pubmed-article:2297560 | pubmed:author | pubmed-author:JongDD | lld:pubmed |
| pubmed-article:2297560 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2297560 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:2297560 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2297560 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2297560 | pubmed:pagination | 147-52 | lld:pubmed |
| pubmed-article:2297560 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:meshHeading | pubmed-meshheading:2297560-... | lld:pubmed |
| pubmed-article:2297560 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2297560 | pubmed:articleTitle | Enantiomeric effects on excitation-contraction coupling in frog skeletal muscle by a chiral phenoxy carboxylic acid. | lld:pubmed |
| pubmed-article:2297560 | pubmed:affiliation | Department of Physiology and Biophysics, University of Cincinnati, Ohio 45267-0576. | lld:pubmed |
| pubmed-article:2297560 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2297560 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2297560 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2297560 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2297560 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2297560 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2297560 | lld:pubmed |
