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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-3-5
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pubmed:abstractText |
Aromatic monocarboxylic acids are known to significantly potentiate the mechanical response of skeletal muscle fibers. In this study we investigated the effects of enantiomers of 2-(4-chlorophenoxy)propionic acid, chemically one of the simplest aromatic monocarboxylic acids with chiral properties, on mechanical threshold and charge movement in frog skeletal muscle. The R(+), but not the S(-), enantiomer lowered rheobase mechanical threshold and shifted charge movement to more negative potentials. The R(+) enantiomer also significantly slowed charge movement kinetics, with pronounced delays of the OFF charge transitions. These effects required high temperature for their production. The stereospecific actions of the R(+) enantiomer are interpreted in terms of a specific interaction of this compound at an anion-sensitive site involved in excitation-contraction coupling, most likely on the dihydropryidine-sensitive voltage sensor in the T-system.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-1082506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-14192183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-2434854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-2441051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-2450990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-2464159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-289314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-2903448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-3039123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-321754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-3264838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-3382714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-5316641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-5318082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-5352046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-5698275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-6311303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-6315919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2297560-894246
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1990
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pubmed:articleTitle |
Enantiomeric effects on excitation-contraction coupling in frog skeletal muscle by a chiral phenoxy carboxylic acid.
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pubmed:affiliation |
Department of Physiology and Biophysics, University of Cincinnati, Ohio 45267-0576.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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