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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1990-2-16
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pubmed:abstractText |
Three patients with mitochondrial myopathies and progressive external ophthalmoplegia had repeated episodes of respiratory failure requiring assisted ventilation. Studies in these patients and asymptomatic family members, as well as a sporadic case of Kearns-Sayre syndrome, demonstrated markedly depressed ventilatory drive responses to hypoxia. In 2 patients, there was also decreased drive to hypercapnia. The reduced ventilatory drive appears to be due to an altered neural control system that may cause episodic life-threatening hypoventilation occurring especially in relation to surgery, sedation, or intercurrent infection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-3878
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2296355-Adult,
pubmed-meshheading:2296355-Aged,
pubmed-meshheading:2296355-Child,
pubmed-meshheading:2296355-Female,
pubmed-meshheading:2296355-Humans,
pubmed-meshheading:2296355-Male,
pubmed-meshheading:2296355-Mitochondria, Muscle,
pubmed-meshheading:2296355-Muscular Diseases,
pubmed-meshheading:2296355-Ophthalmoplegia,
pubmed-meshheading:2296355-Recurrence,
pubmed-meshheading:2296355-Respiration, Artificial,
pubmed-meshheading:2296355-Respiratory Function Tests,
pubmed-meshheading:2296355-Respiratory Insufficiency
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pubmed:year |
1990
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pubmed:articleTitle |
Recurrent respiratory insufficiency and depressed ventilatory drive complicating mitochondrial myopathies.
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pubmed:affiliation |
Department of Neurology, Ohio State University College of Medicine, Columbus 43210.
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pubmed:publicationType |
Journal Article
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