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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1990-2-22
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pubmed:abstractText |
Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized. Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b) on HMG-CoA reductase, both in vitro and in vivo. First clinical trials with 2i (HR 780) are in preparation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
52-60
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2296036-Acetates,
pubmed-meshheading:2296036-Animals,
pubmed-meshheading:2296036-Anticholesteremic Agents,
pubmed-meshheading:2296036-Chemical Phenomena,
pubmed-meshheading:2296036-Chemistry,
pubmed-meshheading:2296036-Cholesterol,
pubmed-meshheading:2296036-Heptanoic Acids,
pubmed-meshheading:2296036-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:2296036-Lactones,
pubmed-meshheading:2296036-Liver,
pubmed-meshheading:2296036-Liver Neoplasms, Experimental,
pubmed-meshheading:2296036-Male,
pubmed-meshheading:2296036-Molecular Conformation,
pubmed-meshheading:2296036-Molecular Structure,
pubmed-meshheading:2296036-Pyridines,
pubmed-meshheading:2296036-Pyrimidines,
pubmed-meshheading:2296036-Rabbits,
pubmed-meshheading:2296036-Rats,
pubmed-meshheading:2296036-Structure-Activity Relationship,
pubmed-meshheading:2296036-Tumor Cells, Cultured,
pubmed-meshheading:2296036-X-Ray Diffraction
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pubmed:year |
1990
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pubmed:articleTitle |
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.
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pubmed:affiliation |
Hoechst AG, Frankfurt/M, West Germany.
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pubmed:publicationType |
Journal Article
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