Linked Life Data

2295843

Source:http://linkedlifedata.com/resource/pubmed/id/2295843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-13
pubmed:abstractText
A prospective study compared the levels of inflammatory mediators in nasal lavages from noninfected, asymptomatic subjects with the mediator content of lavages from the same subjects during naturally occurring rhinovirus colds. Samples were obtained from 16 subjects who experienced natural colds that could be attributed to rhinovirus infections. Kinin levels during symptomatic colds were significantly elevated (P less than .01) compared with those measured when the subjects were noninfected and asymptomatic. Increases in kinins correlated with increased vascular permeability, as monitored by increased concentrations of albumin in lavages. In contrast, histamine levels in nasal lavages were not increased during symptomatic infections, suggesting that mast cell and basophil activation does not occur during rhinovirus colds. These data confirm and extend observations made during experimentally induced rhinovirus infections to the natural disease and are consistent with the hypothesis that kinins may play a role in the pathogenesis of symptomatic rhinovirus infections.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Kinins are generated in nasal secretions during natural rhinovirus colds.
pubmed:affiliation
Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't