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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1990-2-20
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pubmed:abstractText |
From January 1984-December 1987, 1783 patients received combination therapy of isoniazid, rifampin, and ethambutol for the control of tuberculosis. Forty-two developed symptomatic hepatitis during the period of treatment. Fifteen were hepatitis B virus carriers, and the remaining 27 were noncarriers. The peak serum transaminase and bilirubin levels were higher in carriers. Seven carriers died of fulminant or subacute hepatic failure, and only 1 noncarrier died. Eleven carriers had detectable serum hepatitis B virus deoxyribonucleic acid during the acute stage of hepatitis. The roles of isoniazid-rifampin combination therapy and hepatitis B virus in the adverse outcomes of carriers were discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-5085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
502-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2295408-Carrier State,
pubmed-meshheading:2295408-Drug Therapy, Combination,
pubmed-meshheading:2295408-Drug-Induced Liver Injury,
pubmed-meshheading:2295408-Ethambutol,
pubmed-meshheading:2295408-Female,
pubmed-meshheading:2295408-Hepatitis B,
pubmed-meshheading:2295408-Humans,
pubmed-meshheading:2295408-Isoniazid,
pubmed-meshheading:2295408-Male,
pubmed-meshheading:2295408-Middle Aged,
pubmed-meshheading:2295408-Rifampin,
pubmed-meshheading:2295408-Tuberculosis, Pulmonary
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pubmed:year |
1990
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pubmed:articleTitle |
Isoniazid-rifampin-induced hepatitis in hepatitis B carriers.
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pubmed:affiliation |
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article
|