Linked Life Data

2293903

Source:http://linkedlifedata.com/resource/pubmed/id/2293903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-1-30
pubmed:abstractText
It has been hypothesized that dietary fat may affect natural killer (NK) cell activity, a factor of potential importance in early tumor surveillance. Fourteen men successfully completed an intervention trial designed to test the effect of dietary fat on NK activity in humans. Study subjects lowered their fat intake to an average of 22% of calories as fat and consumed two dietary supplements (of coconut and safflower oils), in a cross-over design. These supplements resulted in large changes in the ratio of polyunsaturated to saturated fatty acids (1.73 to 0.34, on average). Results of a general linear model in which we fitted covariates on exercise, body mass, intervention sequence, and various dietary predictors revealed a significant effect of decreased total dietary fat intake on increased NK activity at an E/T ratio of 100:1 (about 0.79% increase for each absolute percent of calories as fat, P = 0.04). Similar results were obtained at E/T ratios of 50:1 and 25:1. No other nutritional predictor was significantly associated with NK activity at any E/T ratio.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0090-1229
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-16
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Natural killer cell activity in a longitudinal dietary fat intervention trial.
pubmed:affiliation
Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester 01655.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't