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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1991-4-8
|
| pubmed:abstractText |
Cell lines from 26 human cancers were studied for cytotoxicity when treated with normal pregnancy serum. Cytotoxicity manifested by cell death and cytolysis, occurred in 4 of 8 neuroblastomas studied: SK-N-SH, NGP, LAN-5, and IMR-32. In NGP and SK-N-SH, evidence is presented showing that the cytotoxicity resulted from the cell-surface binding of a natural IgM 'antibody', which sensitized the neuroblastoma cells to the lytic action of complement (C). This system may be involved in a cytolytic form of spontaneous regression of neuroblastoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0735-7907
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-11
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2292053-Cell Line,
pubmed-meshheading:2292053-Cell Survival,
pubmed-meshheading:2292053-Complement System Proteins,
pubmed-meshheading:2292053-Cytotoxicity, Immunologic,
pubmed-meshheading:2292053-Female,
pubmed-meshheading:2292053-Fetal Blood,
pubmed-meshheading:2292053-Humans,
pubmed-meshheading:2292053-Immunoglobulin M,
pubmed-meshheading:2292053-Immunohistochemistry,
pubmed-meshheading:2292053-Neoplasm Regression, Spontaneous,
pubmed-meshheading:2292053-Neuroblastoma,
pubmed-meshheading:2292053-Pregnancy,
pubmed-meshheading:2292053-Tumor Cells, Cultured
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The cytolysis of human neuroblastoma cells by a natural IgM 'antibody'-complement system in pregnancy serum.
|
| pubmed:affiliation |
Department of Pathology, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
|
| pubmed:publicationType |
Journal Article
|