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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-11
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|
pubmed:abstractText |
Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
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pubmed:issn |
0361-9230
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-400
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2292036-Angiotensin II,
pubmed-meshheading:2292036-Animals,
pubmed-meshheading:2292036-Autoradiography,
pubmed-meshheading:2292036-Brain Chemistry,
pubmed-meshheading:2292036-Imidazoles,
pubmed-meshheading:2292036-Iodine Radioisotopes,
pubmed-meshheading:2292036-Losartan,
pubmed-meshheading:2292036-Male,
pubmed-meshheading:2292036-Pyridines,
pubmed-meshheading:2292036-Rats,
pubmed-meshheading:2292036-Receptors, Angiotensin,
pubmed-meshheading:2292036-Tetrazoles
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Evidence for the presence of angiotensin II-type 1 receptors in brain.
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pubmed:affiliation |
Neuropsychiatric Research Institute, Fargo, ND 58103.
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pubmed:publicationType |
Journal Article
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