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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1991-4-2
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pubmed:abstractText |
Acetylenic spirobutenolide amides and esters and their Mannich bases were synthesized to evaluate their growth inhibitory effect. The biological tests have used both normal and transformed cells and they have shown the selectivity of the prepared compounds. The ester derivatives presented the best selectivity comparable to that of daunorubicin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-4172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1135-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2291752-Antineoplastic Agents,
pubmed-meshheading:2291752-Cell Division,
pubmed-meshheading:2291752-Cell Transformation, Neoplastic,
pubmed-meshheading:2291752-Cells, Cultured,
pubmed-meshheading:2291752-Chemical Phenomena,
pubmed-meshheading:2291752-Chemistry,
pubmed-meshheading:2291752-Chemistry, Physical,
pubmed-meshheading:2291752-HeLa Cells,
pubmed-meshheading:2291752-Humans,
pubmed-meshheading:2291752-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2291752-Mannich Bases,
pubmed-meshheading:2291752-Neoplasm Proteins,
pubmed-meshheading:2291752-Ornithine Decarboxylase,
pubmed-meshheading:2291752-Physicochemical Phenomena,
pubmed-meshheading:2291752-Spiro Compounds
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pubmed:year |
1990
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pubmed:articleTitle |
Synthesis of acetylenic spirobutenolide derivatives and evaluation of their growth inhibitory effect on cells in culture.
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pubmed:affiliation |
Laboratoire de Chimie, Thérapeutique, Faculté de Pharmacie, Lyon, France.
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pubmed:publicationType |
Journal Article
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