Linked Life Data

2290200

Source:http://linkedlifedata.com/resource/pubmed/id/2290200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-4-4
pubmed:abstractText
We have developed a simple method to quantitate brain perfusion SPECT with N-isopropyl-p-[123I]iodoamphetamine (IMP). After an intravenous bolus injection of IMP, serial dynamic images of the brain and the lung were obtained every 5 sec for 2 min, followed by a SPECT scan at 20 min. Based on the assumption of IMP as chemical microspheres, fractional uptake (FU) of IMP in the brain was calculated from the time-activity curves of the total brain and the total lungs. FU showed a strong positive correlation with inverse of the body surface area which was calculated from the height and weight of the individual subject, suggesting that FU is influenced by cardiac output. Quantification of IMP brain perfusion SPECT was attempted with FU and estimated cardiac output in each subject, providing an index of regional cerebral blood flow. Compared with PET measurement of regional cerebral blood flow, the present method tended to overestimate the flow values. This method has a great advantage that it can be applied in many institutions having large field gamma cameras. However, the accuracy of the measurement may be limited in the tall subjects and in the cases with cardiopulmonary diseases, and further investigation is required to clarify the usefulness and limitation of this approach.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-7854
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1311-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Simple quantification of brain perfusion SPECT with IMP using a large field gamma camera].
pubmed:affiliation
Department of Brain Pathophysiology, Kyoto University Faculty of Medicine, Japan.
pubmed:publicationType
Journal Article, English Abstract