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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-4-1
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pubmed:abstractText |
Many of the circulating algesic agents released in response to ischemia produce a profound vasodilatation possibly through the release of an endothelium-derived relaxing factor (EDRF) as well as pain. We report here that intravenously administered S-nitrosocysteine, a putative EDRF, and not the nitric oxide liberating compound sodium nitroprusside produces significant alterations in nociceptive behavior that are abolished by bilateral vagotomy. These results are consistent with a role for EDRF in peripheral nociceptive mechanisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
531
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
342-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2289134-Analysis of Variance,
pubmed-meshheading:2289134-Animals,
pubmed-meshheading:2289134-Blood Pressure,
pubmed-meshheading:2289134-Cysteine,
pubmed-meshheading:2289134-Heart Rate,
pubmed-meshheading:2289134-Male,
pubmed-meshheading:2289134-Nitric Oxide,
pubmed-meshheading:2289134-Nitroprusside,
pubmed-meshheading:2289134-Pain,
pubmed-meshheading:2289134-Rats,
pubmed-meshheading:2289134-Rats, Inbred Strains,
pubmed-meshheading:2289134-S-Nitrosothiols,
pubmed-meshheading:2289134-Vagotomy
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pubmed:year |
1990
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pubmed:articleTitle |
Is there a role for an endothelium-derived relaxing factor in nociception?
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pubmed:affiliation |
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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