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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
1991-3-27
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pubmed:abstractText |
In vitro exposure of estrogen receptor-negative (ER-) EVSA-T human breast cancer cells to insulin and/or estradiol had no effect on cell cycle distribution, in contrast to a 3-5-fold increase in the percentages of cells in the S-phase of the cell cycle in the ER+ MCF-7 cell line. Estrogen pretreatment of MCF-7 cells followed by incubation with doxorubicin resulted in an augmented inhibition of cell growth compared to unstimulated controls. This delay in growth was accompanied by a decrease in the percentages of cells actively synthesizing DNA, and by an augmented percentage of cells exhibiting a G2M-amount of DNA at the end of a 6-9 day period of culture in complete growth medium.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
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pubmed:issn |
0960-0760
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
20
|
|
pubmed:volume |
37
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1097-101
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2285583-Breast Neoplasms,
pubmed-meshheading:2285583-Bromodeoxyuridine,
pubmed-meshheading:2285583-Cell Cycle,
pubmed-meshheading:2285583-DNA,
pubmed-meshheading:2285583-Doxorubicin,
pubmed-meshheading:2285583-Estradiol,
pubmed-meshheading:2285583-Female,
pubmed-meshheading:2285583-Flow Cytometry,
pubmed-meshheading:2285583-Humans,
pubmed-meshheading:2285583-Insulin,
pubmed-meshheading:2285583-Kinetics,
pubmed-meshheading:2285583-Receptors, Estrogen,
pubmed-meshheading:2285583-Tumor Cells, Cultured
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|
pubmed:year |
1990
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|
pubmed:articleTitle |
Manipulation of cell cycle kinetics: influence on the cytotoxicity of doxorubicin in human breast cancer cells.
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|
pubmed:affiliation |
Division of Endocrine Oncology (Department of Medical Oncology), Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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