|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010362,
umls-concept:C0017725,
umls-concept:C0020538,
umls-concept:C0021641,
umls-concept:C0030705,
umls-concept:C0032821,
umls-concept:C0087111,
umls-concept:C0541746,
umls-concept:C1156530,
umls-concept:C1274040,
umls-concept:C1280500,
umls-concept:C1511790,
umls-concept:C1522577,
umls-concept:C2728259
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1991-3-15
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|
pubmed:abstractText |
Fasting and one hour post-glucose load blood samples were obtained from 497 participants in the Hypertension Detection and Follow-up Program (HDFP), 79.8% of whom were on antihypertensive therapy at the time of their five-year examination. Major findings include a positive correlation between glucose/insulin ratio and serum potassium (P = 0.0014) and a weaker negative correlation between fasting insulin and serum potassium (P = 0.004). These data are compatible with a primary effect of hypokalaemia producing insulin 'resistance'. In addition, the glucose load was followed by a mean reduction in serum potassium of 0.135 +/- 0.525 meq/l (P less than 0.001). Twenty percent of participants experienced a drop of more than 0.5 meq/l. Cholesterol was associated with the fasting glucose/insulin ratio (P less than 0.032). The results are compatible with the hypothesis that prevention of hypokalaemia may prevent certain metabolic effects attributed to thiazide.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-9240
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
4
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
491-500
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|
pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2283639-Adult,
pubmed-meshheading:2283639-Aged,
pubmed-meshheading:2283639-Benzothiadiazines,
pubmed-meshheading:2283639-Cholesterol,
pubmed-meshheading:2283639-Cohort Studies,
pubmed-meshheading:2283639-Cross-Sectional Studies,
pubmed-meshheading:2283639-Diuretics,
pubmed-meshheading:2283639-Female,
pubmed-meshheading:2283639-Follow-Up Studies,
pubmed-meshheading:2283639-Glucose,
pubmed-meshheading:2283639-Humans,
pubmed-meshheading:2283639-Hypertension,
pubmed-meshheading:2283639-Hypokalemia,
pubmed-meshheading:2283639-Insulin,
pubmed-meshheading:2283639-Male,
pubmed-meshheading:2283639-Middle Aged,
pubmed-meshheading:2283639-Potassium,
pubmed-meshheading:2283639-Sodium Chloride Symporter Inhibitors
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|
pubmed:year |
1990
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pubmed:articleTitle |
The effect of thiazide therapy on glucose, insulin and cholesterol metabolism and of glucose on potassium: results of a cross-sectional study in patients from the Hypertension Detection and Follow-up Program.
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|
pubmed:affiliation |
Department of Medicine, University of Mississippi Medical Center, Jackson 39216-5405.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|
