| pubmed-article:2282529 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C0235032 | lld:lifeskim |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C0025991 | lld:lifeskim |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2282529 | lifeskim:mentions | umls-concept:C0037239 | lld:lifeskim |
| pubmed-article:2282529 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:2282529 | pubmed:dateCreated | 1991-3-21 | lld:pubmed |
| pubmed-article:2282529 | pubmed:abstractText | Microinjection of the D-1 agonist R-SKF 38393 into rat striatum resulted in extensive neurotoxic damage as revealed by the presence of large lesions upon histological analysis. These lesions were observed following a single injection of the drug into the ventrolateral striatum (30 micrograms/0.5 microliters) or nucleus accumbens (3.0 or 30 micrograms/0.5 microliters). This neurotoxic damage was also observed following microinjection of the inactive isomer S-SKF 38393. The mechanisms underlying these effects are presently unknown. The use of this compound for intracerebral microinjection studies should be re-evaluated. In view of the usefulness of central microinjections in studying the role of D-1 and D-2 receptors in behavior, it is suggested that alternative D-1 agonists, or ways of minimizing the toxicity of SKF 38393, should be considered. | lld:pubmed |
| pubmed-article:2282529 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2282529 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2282529 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2282529 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2282529 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2282529 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2282529 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2282529 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:2282529 | pubmed:author | pubmed-author:KelleyA EAE | lld:pubmed |
| pubmed-article:2282529 | pubmed:author | pubmed-author:CidLL | lld:pubmed |
| pubmed-article:2282529 | pubmed:author | pubmed-author:DelfsJ MJM | lld:pubmed |
| pubmed-article:2282529 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2282529 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:2282529 | pubmed:volume | 532 | lld:pubmed |
| pubmed-article:2282529 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2282529 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2282529 | pubmed:pagination | 342-6 | lld:pubmed |
| pubmed-article:2282529 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:meshHeading | pubmed-meshheading:2282529-... | lld:pubmed |
| pubmed-article:2282529 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2282529 | pubmed:articleTitle | Neurotoxicity induced by the D-1 agonist SKF 38393 following microinjection into rat brain. | lld:pubmed |
| pubmed-article:2282529 | pubmed:affiliation | Department of Psychology, Harvard University, Cambridge, MA 02138. | lld:pubmed |
| pubmed-article:2282529 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2282529 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2282529 | lld:pubmed |
