Linked Life Data

2282529

Source:http://linkedlifedata.com/resource/pubmed/id/2282529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1991-3-21
pubmed:abstractText
Microinjection of the D-1 agonist R-SKF 38393 into rat striatum resulted in extensive neurotoxic damage as revealed by the presence of large lesions upon histological analysis. These lesions were observed following a single injection of the drug into the ventrolateral striatum (30 micrograms/0.5 microliters) or nucleus accumbens (3.0 or 30 micrograms/0.5 microliters). This neurotoxic damage was also observed following microinjection of the inactive isomer S-SKF 38393. The mechanisms underlying these effects are presently unknown. The use of this compound for intracerebral microinjection studies should be re-evaluated. In view of the usefulness of central microinjections in studying the role of D-1 and D-2 receptors in behavior, it is suggested that alternative D-1 agonists, or ways of minimizing the toxicity of SKF 38393, should be considered.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
532
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
342-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Neurotoxicity induced by the D-1 agonist SKF 38393 following microinjection into rat brain.
pubmed:affiliation
Department of Psychology, Harvard University, Cambridge, MA 02138.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.