Linked Life Data

2282511

Source:http://linkedlifedata.com/resource/pubmed/id/2282511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1991-3-21
pubmed:abstractText
The objective of the present study was to determine in vivo the effects of opioids applied locally via microiontophoresis on physiologically characterized laminae I and II dorsal horn neurons in the cat spinal cord. Experiments were performed on pentobarbital-anesthetized or decerebrate, spinalized cats. The effects of morphine (MOR), [D-Ala2,methyl-Phe4, Gly-ol5]enkephalin (DAGO) and naloxone (NALO) on spontaneous- and D,L-homocysteic acid-evoked unit activity were examined for 94 laminae I and II dorsal horn neurons. MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited. Whether MOR, DAGO or NALO exerted excitatory or inhibitory influences on unit activity did not depend on the modality of the neuron (66% of high threshold units, 56% of multireceptive units and 69% of low threshold units were inhibited; some cells of each modality also were excited). NALO also was found rarely to be neutral; 75% of the cells examined were inhibited and 16% excited by NALO. Since NALO was found to itself have significant effects on laminae I and II dorsal horn unit activity, the ability to use NALO as an opioid antagonist to MOR and DAGO was confounded.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
532
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
160-74
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of iontophoresed opioids on physiologically characterized laminae I and II dorsal horn neurons in the cat spinal cord.
pubmed:affiliation
Department of Pharmacology, College of Medicine, University of Oklahoma, Oklahoma City 73190.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.