Linked Life Data

2282492

Source:http://linkedlifedata.com/resource/pubmed/id/2282492

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1991-3-19
pubmed:abstractText
Pre- and postembedding immunocytochemical procedures were used, together with antisera raised against oxytocin or its neurophysin, to characterize oxytocinergic pathways in the rat spinal cord, at the electron microscopic level. Pre-embedding immunoperoxidase staining performed on vibratome sections revealed oxytocin- and neurophysin-positive axonal profiles and terminals scattered predominantly in laminae I and II of the dorsal horn and in the central gray (lamina X). They were also visible, but to a lesser extent, in the intermediolateral columns, at thoracic and lumbar levels. Postembedding immunogold staining performed directly on ultrathin sections of the same areas, fixed in osmium and embedded in resin, permitted to show clearly that the oxytocinergic axons made symmetrical and asymmetrical synaptic contacts onto dendritic profiles. It also allowed subcellular localization of the neuropeptide immunoreactivities which were restricted to relatively large, electron-dense vesicles in the immunopositive terminals. Oxytocinergic terminals were never seen to participate in glomerular configurations in the superficial layers of the dorsal horn nor were immunoreactive cell bodies visible in any spinal area. Our results provide direct morphological evidence that oxytocinergic pathways make synapses in several regions of the spinal cord, thus supporting the contention that oxytocin may exert neurotransmitter/neuromodulator actions in this area of the CNS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
529
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
178-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Oxytocinergic innervation of the rat spinal cord. An electron microscopic study.
pubmed:affiliation
Unité de Recherches de Neurobiologie des Comportements, I.N.S.E.R.M. U.176, University of Bordeaux II, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't