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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-3-15
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pubmed:abstractText |
We have investigated the effect of prostaglandin E1 (PGE1) on non-adrenergic, non-cholinergic (NANC) contraction in guinea-pig bronchial strips. PGE1 (10 nM to 10 microM) did not alter baseline tension but reduced NANC contractions induced by electrical field stimulation (EFS) in a concentration-dependent fashion (-log EC50 was 6.60 +/- 0.10 M and maximum inhibition was 88.7 +/- 2.9%). PGE1 (greater than 0.3 microM) also reduced the contraction induced by substance P (1 microM). Removal of epithelium did not alter the effects of PGE1 on NANC contraction. These results suggest that PGE1 exerts both pre- and post-junctional inhibitory actions on NANC contraction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2282455-Alprostadil,
pubmed-meshheading:2282455-Animals,
pubmed-meshheading:2282455-Autonomic Nervous System,
pubmed-meshheading:2282455-Bronchi,
pubmed-meshheading:2282455-Dinoprostone,
pubmed-meshheading:2282455-Electric Stimulation,
pubmed-meshheading:2282455-Guinea Pigs,
pubmed-meshheading:2282455-Male,
pubmed-meshheading:2282455-Muscle, Smooth,
pubmed-meshheading:2282455-Muscle Contraction,
pubmed-meshheading:2282455-Neurons, Afferent,
pubmed-meshheading:2282455-Nicotinic Acids,
pubmed-meshheading:2282455-Oxadiazoles
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibitory actions of prostaglandin E1 on non-adrenergic non-cholinergic contraction in guinea-pig bronchi.
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pubmed:affiliation |
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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