Linked Life Data

2282139

Source:http://linkedlifedata.com/resource/pubmed/id/2282139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-3-18
pubmed:abstractText
5-Aminolevulinic acid is the first committed precursor for the synthesis of porphyrins such as hemes and chlorophylls. In many organisms aminolevulinate is synthesized from glutamate in a three-step pathway (C5 pathway). The key step in this conversion is a tRNA-mediated reduction of glutamate to glutamate-1-semialdehyde. tRNA is a specific cofactor for an NADPH-dependent enzyme, Glu-tRNA reductase, which is capable of sequence-specific recognition of Glu-tRNA(Glu). tRNA(Glu) is a dual-function molecule; it participates both in protein and in aminolevulinate biosynthesis. This reduction reaction represents a novel role for tRNA where it participates in a metabolic conversion of its amino acid into a low molecular weight metabolite which is subsequently not used in peptide bond synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0951-6433
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Transfer RNA and the formation of the heme and chlorophyll precursor, 5-aminolevulinic acid.
pubmed:affiliation
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review