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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1980-1-19
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pubmed:abstractText |
Synthetic phospholipid vesicles (liposomes) containing the purified glycoprotein (G) of vesicular stomatitis virus (VSV) and solubilized membrane proteins from cells of the appropriate H-2 haplotype elicited H-2-restricted cytotoxic T lymphocytes (CTL) that lysed VSV-infected target cells. The CTL were elicited by intact liposomes, not by released components. Thus, when spleen cells from VSV-primed H-2d X H-2b hybrid mice were stimulated with liposomes having G protein + membrane proteins from cells with one of the parental H-2 haplotypes, the resulting CTL lysed only VSV-infected target cells with that parent's H-2 type. This result argues against the view that T cells in general recognize only processed antigenic fragments on macrophages. Moreover, liposomes were only effective when G protein and cell membrane proteins were included in the same vesicles. This result suggests that for effective interaction with CTL precursors the antigen (G protein) and products of the H-2 complex must be closer to each other than 600--1,000 angstrom, the diameter of the lipid vesicles used in this study.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-204941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-209339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-214512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-215317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-303568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-305464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-309916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-310125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-311817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-312858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-4118869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-4272159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-4321928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-58463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-667034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-75237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227980-77879
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1067-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:227980-Animals,
pubmed-meshheading:227980-Antigens, Viral,
pubmed-meshheading:227980-Crosses, Genetic,
pubmed-meshheading:227980-Cytotoxicity, Immunologic,
pubmed-meshheading:227980-H-2 Antigens,
pubmed-meshheading:227980-Immunologic Memory,
pubmed-meshheading:227980-Liposomes,
pubmed-meshheading:227980-Membrane Proteins,
pubmed-meshheading:227980-Mice,
pubmed-meshheading:227980-Mice, Inbred BALB C,
pubmed-meshheading:227980-Spleen,
pubmed-meshheading:227980-T-Lymphocytes,
pubmed-meshheading:227980-Vesicular stomatitis Indiana virus
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pubmed:year |
1979
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pubmed:articleTitle |
Synthetic phospholipid vesicles containing a purified viral antigen and cell membrane proteins stimulate the development of cytotoxic T lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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