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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-3-13
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pubmed:abstractText |
Biologically active interleukin-1 (IL-1) has been detected in supernatants of draining lymph node cells isolated from contact-sensitized mice. Induction of IL-1 was dependent upon the concentration of sensitizer applied and occurred within 2 hr of exposure. The IL-1 activity could not be attributed to other interleukins and was neutralized by a specific antiserum. Reduced concentrations of IL-1 were produced by cells isolated from the draining nodes of mice that had been pre-exposed to the sensitizer. Since IL-1 has the potential to influence several aspects of lymphocyte activation, the production of significant concentrations of biologically active IL-1 by draining lymph node cells indicates that it is likely to play an important role in the afferent phase of contact sensitization.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2466396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2469644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2522495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2759716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2786913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2789244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2933048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2950198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2958419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-2969406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-3257250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2279734-3260188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2279734-Animals,
pubmed-meshheading:2279734-Cell Division,
pubmed-meshheading:2279734-Cells, Cultured,
pubmed-meshheading:2279734-Dermatitis, Contact,
pubmed-meshheading:2279734-Ear, External,
pubmed-meshheading:2279734-Interleukin-1,
pubmed-meshheading:2279734-Kinetics,
pubmed-meshheading:2279734-Lymph Nodes,
pubmed-meshheading:2279734-Mice,
pubmed-meshheading:2279734-Mice, Inbred BALB C,
pubmed-meshheading:2279734-Oxazolone
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pubmed:year |
1990
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pubmed:articleTitle |
Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice.
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pubmed:affiliation |
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, U.K.
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pubmed:publicationType |
Journal Article
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