| pubmed-article:2279702 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C0597519 | lld:lifeskim |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:2279702 | lifeskim:mentions | umls-concept:C1883220 | lld:lifeskim |
| pubmed-article:2279702 | pubmed:issue | 12B | lld:pubmed |
| pubmed-article:2279702 | pubmed:dateCreated | 1991-3-14 | lld:pubmed |
| pubmed-article:2279702 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2279702 | pubmed:abstractText | HNF-4 (hepatocyte nuclear factor 4) is a protein enriched in liver extracts that binds to sites required for the transcription of the genes for transthyretin (TTR), the carrier protein in the serum for vitamin A and thyroid hormone, and for apolipoprotein CIII (apoCIII), a major constituent of chylomicrons and very low-density lipoproteins (VLDL). Synthetic oligonucleotides derived from amino acid sequence of affinity-purified HNF-4 protein (54 kD) were used in the polymerase chain reaction (PCR) to isolate a cDNA clone encoding the protein. HNF-4 is a member of the steroid hormone receptor superfamily with an unusual amino acid in the conserved "knuckle" of the first zinc finger (DGCKG). Studies with in vitro-translated HNF-4 protein show that it binds to its recognition site as a dimer, and cotransfection assays indicate that it activates transcription in a sequence-specific fashion in nonhepatic (HeLa) cells. Northern blot analysis reveals that HNF-4 mRNA is present in kidney and intestine, as well as liver, but is absent in other tissues. DNA-binding and antisera reactivity data suggest that HNF-4 could be identical to liver factor A1 (LF-A1), a DNA-binding activity implicated in the regulation of transcription of the alpha 1-antitrypsin, apolipoprotein A1, and pyruvate kinase genes. The similarity between HNF-4 and other ligand-dependent transcription factors raises the possibility that HNF-4 and the genes it regulates respond to an as yet unidentified ligand. | lld:pubmed |
| pubmed-article:2279702 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2279702 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2279702 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2279702 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2279702 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:2279702 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:2279702 | pubmed:author | pubmed-author:LalFF | lld:pubmed |
| pubmed-article:2279702 | pubmed:author | pubmed-author:DarnellJ... | lld:pubmed |
| pubmed-article:2279702 | pubmed:author | pubmed-author:SladekF MFM | lld:pubmed |
| pubmed-article:2279702 | pubmed:author | pubmed-author:ZhongW MWM | lld:pubmed |
| pubmed-article:2279702 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2279702 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:2279702 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2279702 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2279702 | pubmed:pagination | 2353-65 | lld:pubmed |
| pubmed-article:2279702 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2279702 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2279702 | pubmed:articleTitle | Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. | lld:pubmed |
| pubmed-article:2279702 | pubmed:affiliation | Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021. | lld:pubmed |
| pubmed-article:2279702 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2279702 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2279702 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2279702 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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