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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1980-1-28
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pubmed:abstractText |
Experimental myocardial ischemia produced in dogs by proximal left anterior descending coronary artery ligation is accompanied by relatively rapid (1 h) increases in the number of (-) [3H]dihydroalprenolol binding sites without changing their dissociation constants in ischemic left ventricular tissue. The changes, persist for at least 8 h and are accompanied by marked decreases in myocardial tissue ischemic region norepinephrine content. In contrast, in the same canine model 1 h of proximal left anterior descending coronary artery ligation did not result in a significant change in the number of [3H]quinuclidynl benzilate binding sites of their dissociation constants. However, the number of [3H]quinuclidynl benzilate binding sites (muscarinic cholinergic receptors) are 50--70% greater than (-) [3H]dihydroalprenolol binding sites (beta adrenergic receptors) in canine left ventricular tissue. Thus, the data suggest that proximal left anterior descending coronary artery occlusion for 1 h significantly increases the number of beta adrenergic receptors in ischemic left ventricular tissue without changing the number of muscarinic cholinergic receptors. Whether the ischemia-produced increase in cardiac beta-receptor content is causally related to increased cyclic AMP levels that develop in ischemic tissue and/or an etiologic factor in arrhythmias originating from ischemic myocardial tissue will have to be determined in additional studies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-1057183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-10626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-1245597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-13744859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-14347090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-15999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-167023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-168037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-201667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-202713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-205804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-207354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-4355036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-4373745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-4390191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-4736667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-5539546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227935-641068
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dihydroalprenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidinyl Benzilate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholinergic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1423-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:227935-Animals,
pubmed-meshheading:227935-Coronary Disease,
pubmed-meshheading:227935-Coronary Vessels,
pubmed-meshheading:227935-Dihydroalprenolol,
pubmed-meshheading:227935-Dogs,
pubmed-meshheading:227935-Female,
pubmed-meshheading:227935-Ligation,
pubmed-meshheading:227935-Male,
pubmed-meshheading:227935-Myocardium,
pubmed-meshheading:227935-Norepinephrine,
pubmed-meshheading:227935-Quinuclidinyl Benzilate,
pubmed-meshheading:227935-Receptors, Adrenergic,
pubmed-meshheading:227935-Receptors, Adrenergic, beta,
pubmed-meshheading:227935-Receptors, Cholinergic,
pubmed-meshheading:227935-Receptors, Muscarinic
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pubmed:year |
1979
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pubmed:articleTitle |
Beta adrenergic and muscarinic cholinergic receptors in canine myocardium. Effects of ischemia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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