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rdf:type |
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lifeskim:mentions |
umls-concept:C0003253,
umls-concept:C0086418,
umls-concept:C0162388,
umls-concept:C0205296,
umls-concept:C0205307,
umls-concept:C0206558,
umls-concept:C0221284,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1980-1-28
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pubmed:abstractText |
Studies of a mouse model of genetic resistance to herpes simplex virus type 1 (HSV-1) indicate that the marrow-dependent effector cell of allogeneic resistance plays an important role in natural resistance to this virus infection. Since the marrow-dependent effector cell appears to be closely related to the natural killer (NK) cells, an NK assay with HSV-1-infected fibroblasts [NK(HSV-1)] has been developed to study this resistance mechanism in humans. Incubation of effector and target cells for 12 to 14 h gave the greatest percent specific release (%SR) and kept spontaneous (51)Cr release from infected target cells below 35%. Patients with Bruton's agammaglobulinemia demonstrated significant kill indicating antiviral antibody was not necessary. Seropositive individuals gave a 9% greater%SR than seronegative individuals. Depletion of B-cells consistently diminished NK (HSV-1) for seropositive individuals and augmented kill for seronegative individuals. Although antiviral antibody produced in culture may contribute to NK (HSV-1), depletion of B-cells allowed quantitation of NK (HSV-1) to the exclusion of most of the antibody-dependent kill. The NK cells detected by this assay showed many of the properties reported for NK cells with K562 targets. Two patients with severe herpesvirus infections demonstrated NK (HSV-1) responses greater than 2 standard deviations below the normal mean. Since normal individuals with virus infections have higher rather than lower natural kill, the low NK (HSV-1) may reflect their susceptibility to the virus infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-109389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-1234049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-140182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-150448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-171586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-173757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-186916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-190582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-191528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-194838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-195708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-300411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-356546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-361888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4114496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4317670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4325096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4353825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4361959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4371311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4372535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4377553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4397663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4610054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-4617294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-593386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-781225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/227799-886188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-56
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:227799-Antibodies, Viral,
pubmed-meshheading:227799-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:227799-Cytotoxicity, Immunologic,
pubmed-meshheading:227799-Female,
pubmed-meshheading:227799-Herpes Simplex,
pubmed-meshheading:227799-Herpesviridae Infections,
pubmed-meshheading:227799-Humans,
pubmed-meshheading:227799-Killer Cells, Natural,
pubmed-meshheading:227799-Male,
pubmed-meshheading:227799-Simplexvirus
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pubmed:year |
1979
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pubmed:articleTitle |
Natural killing of herpes simplex virus type 1-infected target cells: normal human responses and influence of antiviral antibody.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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