Linked Life Data

2277808

Source:http://linkedlifedata.com/resource/pubmed/id/2277808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-3-1
pubmed:abstractText
The effects of endothelin-1, -2 and -3 (ET-1, -2, -3) on lumen diameter of intracerebral arterioles isolated from rat brain were examined. All three ETs produced concentration-dependent decreases in lumen diameter with EC50 values of 0.7, 1.5 and 58 mmol/l for ET-1, ET-2 and ET-3, respectively. The calcium channel antagonist, nicardipine, had no significant effect on ET-1-induced contractions except at a concentration of 1 mumol/l which attenuated the maximum response to ET-1, but had no effect on the EC50 value. The potent vasoconstrictor action of ET on intracerebral arterioles suggest an important role for this peptide in the regulation of the cerebral microvasculature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-7012
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Response of isolated intracerebral arterioles to endothelins.
pubmed:affiliation
SmithKline Beecham Pharmaceuticals, King of Prussia, Pa.
pubmed:publicationType
Journal Article, Comparative Study