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rdf:type |
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lifeskim:mentions |
umls-concept:C0000477,
umls-concept:C0007450,
umls-concept:C0027740,
umls-concept:C0028351,
umls-concept:C0030685,
umls-concept:C0037993,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1549542,
umls-concept:C1948023,
umls-concept:C1963578
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pubmed:issue |
3
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pubmed:dateCreated |
1978-2-18
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pubmed:abstractText |
1. 4-aminopyridine (4-AP, 1 mM) increased noradrenaline (NA) output from the perfused cat spleen at 5 Hz by about fivefold. Enhancement of NA release by 4-AP was reversible. Output of NA induced by potassium was not affected. 2. NA output was doubled at low concentrations (0.1--0.3 mM) of 4-AP, but maximal effect was obtained at 1--3 mM. At 10 mM, it induced spontaneous release of NA which was insensitive to calcium. 3. Insignificant outputs obtained at 5 Hz in 0.1 and 0.3 mM calcium-Krebs solution were markedly enhanced by 4-AP. 4-AP enhanced release at all calcium concentrations up to 5 mM, but maximum output was obtained at 2.5 mM. 4. 4-AP at pH 8.5 was more effective in enhancing NA release than at pH 7.4. 5. 4-AP increased the recovery of intra-arterially infused NA from the control 26 to 47%. 6. 4-AP did not affect release of catecholamines (CA) from the perfused cat adrenal gland by acetylcholine (ACh). 7. It is suggested that 4-AP inactivates potassium current in sympathetic nerves and prolongs the duration of the action potential, thereby allowing a greater influx of calcium ions into the neurone to enhance release of NA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-1004627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-1185652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-1244890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-1244891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-13521010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-13887557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-14013351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-14074566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-14076522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-14286350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-4335803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-4455853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-6030514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-6048013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/22746-974377
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3751
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
272
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-28
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:22746-Animals,
pubmed-meshheading:22746-Calcium,
pubmed-meshheading:22746-Catecholamines,
pubmed-meshheading:22746-Cats,
pubmed-meshheading:22746-Dose-Response Relationship, Drug,
pubmed-meshheading:22746-Hydrogen-Ion Concentration,
pubmed-meshheading:22746-Norepinephrine,
pubmed-meshheading:22746-Perfusion,
pubmed-meshheading:22746-Potassium,
pubmed-meshheading:22746-Pyridines,
pubmed-meshheading:22746-Spleen
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pubmed:year |
1977
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pubmed:articleTitle |
Effect of 4-aminopyridine on release of noradrenaline from the perfused cat spleen by nerve stimulation.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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