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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1991-2-28
|
| pubmed:abstractText |
Nifurtimox is polarographically reducible over the whole pH range, the nitro group being reduced to the hydroxylamine group in a 4e process and subsequently the amine being formed in a 2e process at a pH value below 4. The C = N-N linkage is reduced by a mechanism involving reductive fission of the N-N bond. The differential pulse polarographic peaks for the reduction of the nitro group to the hydroxylamine group at pH 6 were used in developing a new polarographic method for the determination of nifurtimox in pharmaceutical forms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-3549
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
837-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1990
|
| pubmed:articleTitle |
Polarographic study of nifurtimox.
|
| pubmed:affiliation |
Electrochemistry Laboratory, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|