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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1991-2-27
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pubmed:abstractText |
The preparation and antitumor effects of 3'-deamino-3'-morpholino derivatives of pirarubicin are described. Di-N-alkylation of pirarubicin with bis(2-iodoethyl)ether gave 3'-morpholino-pirarubicin, which was converted into its 13-tosylhydrazone, 13-deoxy derivative and 13-(S)- and 13-(R)-dihydro derivatives. Intraperitoneal administration to murine tumors indicated that the effective dose ranges of the compounds having sp3 carbon at C-13 position were broader than those of the compounds having sp2 carbon. By oral administration, 13-(S)-dihydro isomer was more effective than 13-(R)-dihydro isomer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-8820
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1464-70
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2272921-Administration, Oral,
pubmed-meshheading:2272921-Animals,
pubmed-meshheading:2272921-Chromatography, Thin Layer,
pubmed-meshheading:2272921-Dose-Response Relationship, Drug,
pubmed-meshheading:2272921-Doxorubicin,
pubmed-meshheading:2272921-Female,
pubmed-meshheading:2272921-Injections, Intraperitoneal,
pubmed-meshheading:2272921-Leukemia L1210,
pubmed-meshheading:2272921-Leukemia P388,
pubmed-meshheading:2272921-Magnetic Resonance Spectroscopy,
pubmed-meshheading:2272921-Mice,
pubmed-meshheading:2272921-Molecular Structure,
pubmed-meshheading:2272921-Morpholines,
pubmed-meshheading:2272921-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Improved antitumor effects of 3'-deamino-3'-morpholino derivatives of pirarubicin.
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pubmed:affiliation |
Institute of Microbial Chemistry, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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