Linked Life Data

2272328

Source:http://linkedlifedata.com/resource/pubmed/id/2272328

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-2-28
pubmed:abstractText
There is abundant epidemiologic evidence that asbestos fibers can cause lung fibrosis (asbestosis), bronchial cancer, and mesothelioma in humans, as well as limited evidence for such effects in workers exposed to slag and rockwool fibers. Epidemiological evidence for human disease from inhalation exposures to conventional fibrous glass is negative. While health concerns based on the morphological and toxicological similarities between man-made fibers and asbestos are warranted, it is important to note that most of the toxicological evidence for glass fiber toxicity in laboratory animals is based on nonphysiological exposures such as intratracheal instillation or intraperitoneal injection of fiber suspensions. Man-made fibers have produced lung fibrosis and mesotheliomas in such tests, albeit at much lower yields than asbestos. For all durable mineral fibers, critical length limits must be exceeded to warrant concern about chronic toxicity; i.e., 2 microns for asbestosis, 5 microns for mesothelioma, and 10 microns for lung cancer. Fiber width must be less than 0.1 microns for mesothelioma, and larger than this limit for asbestosis and lung cancer. The human health risks for most fibrous glass products are either low or negligible for a variety of reasons. First, most commercial fibrous glass products have mean fiber diameters of approximately 7.5 microns, which results in mean aero-dynamic diameters approximately 22 microns. Thus, most glass fibers, even if dispersed into the air, do not penetrate into the lung to any great extent. Second, the small fraction of smaller diameter fibers that do penetrate into the lungs are not persistent within the lungs for most fibrous glass products due to mechanical breakage into shorter lengths and overall dissolution.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-2835923, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-2986668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3025107, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3026797, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3286241, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3450236, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3450237, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-3450238, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-6260477, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-6267971, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-6282578, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-6625350, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-6636189, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-679903, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-7181257, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-7258930, http://linkedlifedata.com/resource/pubmed/commentcorrection/2272328-7457391
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0091-6765
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effects of fiber characteristics on lung deposition, retention, and disease.
pubmed:affiliation
Institute of Environmental Medicine, New York University Medical Center, Tuxedo 10987.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review