Linked Life Data

2271960

Source:http://linkedlifedata.com/resource/pubmed/id/2271960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-2-26
pubmed:abstractText
After placing bilateral electrolytic lesions in the fasciculus retroflexus (FR) of the rat, the endogenous content of serotonin, glutamate and gamma-aminobutyrate (GABA) as well as choline acetyltransferase activity (ChAT) were measured in the interpeduncular nucleus (IPN) at the 7th, 28th and 120th survival days. Confirming earlier results, an almost total depletion of ChAT was obtained in the IPN following complete FR lesions at any survival day studied. In such cases, the following changes were observed; 1) the serotonin level increased consistently and roughly doubled at the 120th survival day, suggesting heterotypic sprouting of serotonergic fibers and/or enhanced serotonin synthesis in the serotonergic neurons in the IPN, 2) the glutamate level decreased by approximately one-half, while the activity of high affinity uptake of glutamate remained unaltered, at the 7th survival day, suggesting a lowered glutamate formation coupled with lowered glucose utilization in the IPN, and 3) the GABA level decreased at a slower rate and reached one-third of the control at the 120th survival day, for which either transsynaptic degeneration of GABA neurons in the IPN or a suppressed metabolic rate in the GABA shunt following the lowered glutamate formation is a possible explanation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
569-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Differential effects of fasciculus retroflexus lesions on serotonin, glutamate and gamma-aminobutyrate content and choline acetyltransferase activity in the interpeduncular nucleus.
pubmed:affiliation
Department of Physiology, University of Ehime, School of Medicine, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't