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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1991-2-28
|
| pubmed:abstractText |
1. The effect of severe hypothyroidism on the pharmacokinetics and pharmacodynamics of oxazepam 15 mg given orally (n = 10) and the metabolism of paracetamol 750 mg given intravenously (n = 8) was investigated before and after treatment with levothyroxine. 2. The median total and unbound clearance of oxazepam increased significantly during the study period from 0.78 ml min-1 kg-1 (0.40-1.25) to 1.22 ml min-1 kg-1 (0.66-1.94) and from 9.3 ml min-1 kg-1 (5.2-14.2) to 15.9 ml min-1 kg-1 (7.8-21.8), respectively (P less than 0.01). 3. The elimination half-life of oxazepam was prolonged by hypothyroidism to a median (range) value of 9.3 h (5.4-21.9) compared with 7.5 h (4.8-10.5) in the euthyroid state (P less than 0.05). 4. Hypothyroidism did not affect the protein binding of oxazepam; median values of the free percentage being 8.2% as compared with 7.7% when euthyroid. 5. The median (range) clearance of paracetamol under hypothyroid conditions was 3.12 ml min-1 kg-1 (1.64-4.40) and 4.70 ml min-1 kg-1 (3.18-5.70) following replacement therapy (P less than 0.01). This increase was associated with a comparable increase in the partial clearance to the glucuronide metabolite: 1.86 ml min-1 kg-1 to 2.70 ml min-1 kg-1. 6. Hypothyroidism was associated with decreased performance in a finger tapping test that was exacerbated by oxazepam. When the patients were euthyroid oxazepam did not produce any effect.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-3197746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-3709627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-3975258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-4821905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-581029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-6166422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-6419761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-722481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-7249488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-7439247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-7452494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2271373-797503
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0306-5251
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
737-42
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2271373-Acetaminophen,
pubmed-meshheading:2271373-Administration, Oral,
pubmed-meshheading:2271373-Adult,
pubmed-meshheading:2271373-Aged,
pubmed-meshheading:2271373-Female,
pubmed-meshheading:2271373-Humans,
pubmed-meshheading:2271373-Hypothyroidism,
pubmed-meshheading:2271373-Infusions, Intravenous,
pubmed-meshheading:2271373-Male,
pubmed-meshheading:2271373-Metabolic Clearance Rate,
pubmed-meshheading:2271373-Middle Aged,
pubmed-meshheading:2271373-Oxazepam
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism.
|
| pubmed:affiliation |
Department of Internal Medicine F, Gentofte Hospital, Denmark.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|