rdf:type |
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0020792,
umls-concept:C0020861,
umls-concept:C0034788,
umls-concept:C0449432,
umls-concept:C0679058,
umls-concept:C1179435,
umls-concept:C1523873,
umls-concept:C1524073,
umls-concept:C1547699,
umls-concept:C1548799,
umls-concept:C1561491,
umls-concept:C1705248,
umls-concept:C2700640
|
pubmed:issue |
12
|
pubmed:dateCreated |
1991-2-20
|
pubmed:abstractText |
Beside the immunoglobulin (Ig) heavy and light chains the murine B cell receptor of the IgM class contains a heterodimer of two transmembrane proteins (IgM-alpha and Ig-beta). By N-terminal sequencing of IgM-alpha and Ig-beta we have identified the genes encoding these proteins as mb-1 and B29, respectively. Both genes are B cell specific and have been previously cloned from B minus T cell subtractive cDNA libraries. We have constructed expression vectors of the two genes and demonstrate that expression of the mb-1 and B29 genes can influence the surface expression of IgM in micron-transfected myeloma cells. From the known sequences of the IgM-alpha and Ig-beta proteins and from the results of previous transfection experiments with various vectors expressing the mu chain we have developed a structural model of the B cell antigen receptor of class IgM which we compare with that of the T cell antigen receptor.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD79,
http://linkedlifedata.com/resource/pubmed/chemical/Cd79a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0014-2980
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2795-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2269334-Amino Acid Sequence,
pubmed-meshheading:2269334-Animals,
pubmed-meshheading:2269334-Antigens, CD,
pubmed-meshheading:2269334-Antigens, CD79,
pubmed-meshheading:2269334-B-Lymphocytes,
pubmed-meshheading:2269334-Cloning, Molecular,
pubmed-meshheading:2269334-Gene Expression,
pubmed-meshheading:2269334-Genes,
pubmed-meshheading:2269334-Immunoglobulin M,
pubmed-meshheading:2269334-Macromolecular Substances,
pubmed-meshheading:2269334-Membrane Glycoproteins,
pubmed-meshheading:2269334-Mice,
pubmed-meshheading:2269334-Molecular Sequence Data,
pubmed-meshheading:2269334-Receptors, Antigen, B-Cell
|
pubmed:year |
1990
|
pubmed:articleTitle |
Identification of the genes encoding the IgM-alpha and Ig-beta components of the IgM antigen receptor complex by amino-terminal sequencing.
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pubmed:affiliation |
Institut für Genetik, Universität zu Köln, FRG.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|