| pubmed-article:2266772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2266772 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2266772 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:2266772 | lifeskim:mentions | umls-concept:C0037668 | lld:lifeskim |
| pubmed-article:2266772 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:2266772 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2266772 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:2266772 | pubmed:dateCreated | 1991-2-8 | lld:pubmed |
| pubmed-article:2266772 | pubmed:abstractText | This investigation compares the age- and sex-related changes in growth hormone (GH) response to growth hormone releasing hormone (GHRH) in normal subjects using an appropriate pharmacokinetic model. Twenty-five subjects (14 males and 11 females) aged 23-89 yr received a single intravenous bolus dose (1 microgram/kg) of GHRH-40 solution. Plasma GH concentration-time profiles are best characterized by a biexponential equation (or one-compartment model) with first-order release and disappearance rates and an equilibration lag time. The harmonic mean release rate half-life is similar for both sexes (males: 12.6 min vs. females; 11.4 min) but significantly different across age groups (23-35 yr: 7.2 min vs. 50-89 yr: 16.8 min). The mean disappearance rate half-life and GHRH-equilibration time lag for females (33.6 and 20.4 min, respectively) and the higher age group subjects (32.4 and 21.6 min, respectively) are significantly longer than those of males (22.8 and 9 min, respectively) and the lower age-group subjects (21.6 and 8.4 min, respectively). The mean metabolic clearance rate of GH is significantly lower (p less than 0.02) for females than for males (3.1 vs. 4.83 ml/hr.m2). However, the production rate and the amount of GH released by the pituitary for our subjects appear to be very similar for both males (8.7 micrograms/hr.m2 and 4.65 micrograms/m2) and females (9.33 micrograms/hr.m2 and 5.11 micrograms/m2). | lld:pubmed |
| pubmed-article:2266772 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2266772 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2266772 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2266772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2266772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2266772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2266772 | pubmed:issn | 0024-3205 | lld:pubmed |
| pubmed-article:2266772 | pubmed:author | pubmed-author:GuptaS KSK | lld:pubmed |
| pubmed-article:2266772 | pubmed:author | pubmed-author:NemeroffC BCB | lld:pubmed |
| pubmed-article:2266772 | pubmed:author | pubmed-author:RitchieJ CJC | lld:pubmed |
| pubmed-article:2266772 | pubmed:author | pubmed-author:EllinwoodE... | lld:pubmed |
| pubmed-article:2266772 | pubmed:author | pubmed-author:KrishnanR RRR | lld:pubmed |
| pubmed-article:2266772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2266772 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:2266772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2266772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2266772 | pubmed:pagination | 1887-93 | lld:pubmed |
| pubmed-article:2266772 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:meshHeading | pubmed-meshheading:2266772-... | lld:pubmed |
| pubmed-article:2266772 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2266772 | pubmed:articleTitle | Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone. | lld:pubmed |
| pubmed-article:2266772 | pubmed:affiliation | Department of Psychiatry, Duke University Medical Center, Durham, NC 27710. | lld:pubmed |
| pubmed-article:2266772 | pubmed:publicationType | Journal Article | lld:pubmed |
