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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
1991-2-8
|
| pubmed:abstractText |
This investigation compares the age- and sex-related changes in growth hormone (GH) response to growth hormone releasing hormone (GHRH) in normal subjects using an appropriate pharmacokinetic model. Twenty-five subjects (14 males and 11 females) aged 23-89 yr received a single intravenous bolus dose (1 microgram/kg) of GHRH-40 solution. Plasma GH concentration-time profiles are best characterized by a biexponential equation (or one-compartment model) with first-order release and disappearance rates and an equilibration lag time. The harmonic mean release rate half-life is similar for both sexes (males: 12.6 min vs. females; 11.4 min) but significantly different across age groups (23-35 yr: 7.2 min vs. 50-89 yr: 16.8 min). The mean disappearance rate half-life and GHRH-equilibration time lag for females (33.6 and 20.4 min, respectively) and the higher age group subjects (32.4 and 21.6 min, respectively) are significantly longer than those of males (22.8 and 9 min, respectively) and the lower age-group subjects (21.6 and 8.4 min, respectively). The mean metabolic clearance rate of GH is significantly lower (p less than 0.02) for females than for males (3.1 vs. 4.83 ml/hr.m2). However, the production rate and the amount of GH released by the pituitary for our subjects appear to be very similar for both males (8.7 micrograms/hr.m2 and 4.65 micrograms/m2) and females (9.33 micrograms/hr.m2 and 5.11 micrograms/m2).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0024-3205
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1887-93
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2266772-Adult,
pubmed-meshheading:2266772-Aged,
pubmed-meshheading:2266772-Aged, 80 and over,
pubmed-meshheading:2266772-Aging,
pubmed-meshheading:2266772-Female,
pubmed-meshheading:2266772-Growth Hormone,
pubmed-meshheading:2266772-Growth Hormone-Releasing Hormone,
pubmed-meshheading:2266772-Humans,
pubmed-meshheading:2266772-Male,
pubmed-meshheading:2266772-Middle Aged,
pubmed-meshheading:2266772-Pituitary Gland,
pubmed-meshheading:2266772-Sex Characteristics
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Pharmacokinetics of growth hormone secretion in humans induced by growth hormone releasing hormone.
|
| pubmed:affiliation |
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
|
| pubmed:publicationType |
Journal Article
|