Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-2-8
pubmed:abstractText
There is evidence from in vitro systems that the extent of neuronal loss in acute central nervous system ischaemia can be reduced by manoeuvres which restrict availability of glucose to the ischaemic area. Experiments were designed to test whether hypoglycaemia induced with insulin is associated with improved behavioural outcome in a recovery model of stroke. Rats learned a maze task as a test of working memory, believed to be subserved by the hippocampus, and then had a period of cerebral ischaemia, followed by reperfusion. After an interval of 14 days they were tested on the same maze, where lesioned animals had very significant (p less than 0.0001) impairment of working memory, whereas lesioned and treated (2.0 u/kg-1 insulin, minimum single plasma glucose value: 3.1 mmol/l-1) animals were indistinguishable from control animals. It is concluded that a striking degree of protection can be obtained with levels of mild hypoglycaemia which may be acceptable and practicable for use in humans.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-117686, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-205798, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2469161, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2469166, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2469185, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2469186, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2496789, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2646763, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2655186, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2860584, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2910898, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2911838, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-2960530, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3010729, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-30250, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3055442, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3109078, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3129827, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3312514, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3313453, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3343293, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3354026, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3363573, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3602133, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3749297, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3793803, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-3889225, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6149259, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6306230, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6470053, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6538660, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6613531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6661650, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6841465, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-6860182, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-7328139, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-7328140, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-7328145, http://linkedlifedata.com/resource/pubmed/commentcorrection/2266364-7328146
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3050
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
847-53
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Insulin protects cognitive function in experimental stroke.
pubmed:affiliation
Neurosurgery Research Group, Institute of Psychiatry, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't