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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-2-13
|
| pubmed:abstractText |
Multiple myeloma (MM) is characterized by the presence of lytic bone lesion and frequent hypercalcaemia. These are due to an excessive osteoclastic resorption in association with a low bone formation, as demonstrated by bone histomorphometry. Conversely, B-cell malignancies other than MM are rarely associated with lytic bone lesion and/or hypercalcaemia. In this study we have analysed quantitative bone histology in 65 patients with B-cell malignancies other than MM at diagnosis: chronic lymphocytic leukaemia (CLL, n = 20), non-Hodgkin's lymphoma (NHL, n = 25), Waldenström's disease (WD, n = 14), hairy cell leukaemia (HCL, n = 6). Fifty patients presented no clinical evidence of increased bone resorption, including no lytic bone lesions radiologically detectable and/or no hypercalcaemia. 80% of these patients (40/50) had increased bone resorption parameter using quantitative bone histology, including 19/29 (65.5%) patients with CLL or WD and 21/21 (100%) patients with NHL or HCL (P less than 0.01). As a control group, seven patients lacking bone marrow involvement on bone sample presented no excessive bone resorption. However, eight patients presented lytic bone lesions and/or hypercalcaemia. All of these patients had increased resorption parameters with high numbers of osteoclasts per surface trabecular bone (mean = 35.3), as opposed to the patients lacking lytic bone lesions and/or hypercalcaemia (mean = 6.6, n = 28) and to normal individuals (mean +/- SD = 3.8 +/- 1.7 and 6.3 +/- 2.6, respectively before and after 60 years). In all the cases, excessive histologic bone resorption was mediated by mononuclear small osteoclasts (mean osteoclast length +/- SD = 27.3 +/- 4.1 as compared to normal range = 35.0 +/- 1.0, P less than 0.001). In different in vitro models, these small mononuclear osteoclasts are considered as progenitors. These data suggest an abnormal osteoclast differentiation in B-cell malignancies other than MM, probably due to differences in the production of local factors acting on bone remodelling.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
469-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2265108-Adult,
pubmed-meshheading:2265108-Aged,
pubmed-meshheading:2265108-Aged, 80 and over,
pubmed-meshheading:2265108-B-Lymphocytes,
pubmed-meshheading:2265108-Bone Marrow,
pubmed-meshheading:2265108-Bone Resorption,
pubmed-meshheading:2265108-Female,
pubmed-meshheading:2265108-Humans,
pubmed-meshheading:2265108-Leukemia,
pubmed-meshheading:2265108-Lymphoma, Non-Hodgkin,
pubmed-meshheading:2265108-Male,
pubmed-meshheading:2265108-Middle Aged,
pubmed-meshheading:2265108-Multiple Myeloma,
pubmed-meshheading:2265108-Osteochondritis,
pubmed-meshheading:2265108-Osteoclasts
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Micro-osteoclast resorption as a characteristic feature of B-cell malignancies other than multiple myeloma.
|
| pubmed:affiliation |
Departement d'Oncologie Médicale et d'Immunothérapie, Institut du Cancer (Val d'Aurelle II), Montpellier, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|