Linked Life Data

2264459

Source:http://linkedlifedata.com/resource/pubmed/id/2264459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-2-5
pubmed:abstractText
Oxygen is toxic because it produces oxygen radicals. One important oxygen radical generating system is hypoxanthine-xanthine oxidase. Hypoxic newborn babies who have elevated concentrations of hypoxanthine in tissues and body fluids and simultaneously are treated with supplementary oxygen, may therefore produce oxygen radicals in excess overwhelming the body's natural defence systems against free radicals. Further, the capacity of many of these defence systems are probably reduced in the preterm baby. A series of conditions in neonates may, at least partly, be caused by oxygen radicals, e.g. bronchopulmonary dysplasia, retinopathy of prematurity, necrotising enterocolitis and patent ductus arteriosus. These conditions may be different facets of one disease; the "Oxygen radical disease in neonatology". It is speculated that oxygen radicals play a role in regulating the perinatal circulation. This new insight concerning the role of oxygen radicals may have fundamental consequences for treatment and handling of sick newborn babies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0001-656X
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
881-92
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Oxygen toxicity in the neonatal period.
pubmed:affiliation
Department of Paediatrics and Paediatric Research, Rikshospitalet, Oslo, Norway.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't